Título del artículo:

Prediction of patient admission and readmission in adults from a Colombian cohort with bipolar disorder using artificial intelligence

Introduction: Bipolar disorder (BD) is a chronically progressive mental condition, associated with a reduced quality of life and greater disability. Patient admissions are preventable events with a considerable impact on global functioning and social adjustment. While machine learning (ML) approaches have proven prediction ability in other diseases, little is known about their utility to predict patient admissions in this pathology. Aim: To develop prediction models for hospital admission/readmission within 5 years of diagnosis in patients with BD using ML techniques. Methods: The study utilized data from patients diagnosed with BD in a major healthcare organization in Colombia. Candidate predictors were selected from Electronic Health Records (EHRs) and included sociodemographic and clinical variables. ML algorithms, including Decision Trees, Random Forests, Logistic Regressions, and Support Vector Machines, were used to predict patient admission or readmission. Survival models, including a penalized Cox Model and Random Survival Forest, were used to predict time to admission and first readmission. Model performance was evaluated using accuracy, precision, recall, F1 score, area under the receiver operating characteristic curve (AUC) and concordance index. Results: The admission dataset included 2,726 BD patients, with 354 admissions, while the readmission dataset included 352 patients, with almost half being readmitted. The best-performing model for predicting admission was the Random Forest, with an accuracy score of 0.951 and an AUC of 0.98. The variables with the greatest predictive power in the Recursive Feature Elimination (RFE) importance analysis were the number of psychiatric emergency visits, the number of outpatient follow-up appointments and age. Survival models showed similar results, with the Random Survival Forest performing best, achieving an AUC of 0.95. However, the prediction models for patient readmission had poorer performance, with the Random Forest model being again the best performer but with an AUC below 0.70. Conclusion: ML models, particularly the Random Forest model, outperformed traditional statistical techniques for admission prediction. However, readmission prediction models had poorer performance. This study demonstrates the potential of ML techniques in improving prediction accuracy for BD patient admissions.

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Frontiers in Psychiatry

Título del artículo:

Delta power during sleep is modulated by EEG-gated auricular vagal afferent nerve stimulation (EAVANS)

Vagus nerve stimulation (VNS) has many clinical applications under development. In particular, there is a large interest in transcutaneous auricular VNS (taVNS) because it is non-invasive and provides easy access to neuromodulation. The present study proposes a novel approach for electroencephalography (EEG)-gated taVNS, with the ultimate goal of enhancing therapeutic outcomes, including for the treatment of delirium. Delirium arises from an altered state of consciousness and is the most common neuropsychiatric disorder observed in hospitalized patients, especially the elderly. Delirium has been linked to specific disturbances in EEG rhythms. Here, we propose an EEG-gated auricular vagal afferent nerve stimulation (EAVANS) approach to deliver stimulation targeting a specific instantaneous phase of the EEG Delta rhythm to modulate arousal and downstream reduction of neuroinflammation, two of the contributing factors to delirium. We hypothesize that treatment with EAVANS will modulate Delta power, which has been linked with delirium. As dominant Delta power is also a typical feature of non-rapid eye movement (NREM) sleep, we applied a prototype of an EAVANS device on healthy volunteers during sleep to establish preliminary validation. We successfully employed our closed-loop approach to target vagal afference during the rising Delta phase in the range [-π/2 0] radians. We found a significant reduction in Delta wave power for stimulation during the rising Delta phase compared to 1) absence of stimulation, 2) active stimulation during the descending Delta phase, and 3) active stimulation targeting non-vagal territory (i.e. greater auricular nerve) during the rising Delta phase. Further validation of our EEG-gated taVNS approach in the peri-operative period will be needed. As there is presently a lack of effective treatments for delirium, our non-pharmacological and non-invasive approach, if validated, could be easily deployed in clinical settings.Clinical Relevance-Given the serious health consequences and costs associated with delirium, and the absence of effective non-pharmacological treatments, the proposed neuromodulatory approach may be a promising option for reducing delirium and other disorders of consciousness. Our EAVANS prototype system has been tested on healthy volunteers during a NREM sleep state and will require further validation in different patient populations to optimize the proposed technology and gather more evidence to support its clinical utility. This novel non-pharmacological and non-invasive closed-loop neuromodulatory device could be used peri-operatively and in inpatient hospital settings to treat patients at risk of developing delirium. For instance, in a pre-operative setting, this technology may provide an effective preventative \'pre-habilitation\' approach for patients at high risk of developing delirium. Post-operatively, our technology may help manage patients with delirium more effectively.

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Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

Título del artículo:

Comparative efficacy of three anesthetic protocols on cardiac parameters during ovary-hysterectomy in bitches

This study aimed to compare the general electrical heart activity, blood pressure, and heart rate when using three anesthetic protocols for ovariohysterectomy in bitches. In total, 33 healthy canines were selected, distributed in 3 groups of 11 animals each, aged between 1 and 3 years, and with a body weight of 8 to 15 kg from shelters in Bucaramanga, Colombia. Three anesthetic protocols in a completely randomized experimental designwere used. Protocol 1: Ketamine (7 mg/kg) + pentobarbital sodium (1 mg/kg); Protocol 2: Ketamine (7 mg/kg) + propofol (3 mg/kg); Protocol 3: Tiletamine + zolazepam (7 mg/kg). The individual outcomes were classified according to the American Society of Anesthesiologists (ASA I). The results showed that parameters evaluated in the surgical phase significantly increased in patients with Protocol 1 (p<0.05). Protocol 2 showed a better performance in the post-surgical phase (p<0.05) compared with others. Patients with Protocol 3 presented fewer alterations in the electrical conduction of cardiac activity than the other protocols, and quicker recovery after the surgery.

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Revista de Investigaciones Veterinarias del Peru

Título del artículo:

Factors that affect the productivity and competitiveness of the Faculty of Economics, Administrative and Accounting Sciences of the UDES Cúcuta within the framework of the Knowledge Economy.

In the teaching-learning process, the curriculum is a regulatory system that guides and regulates the theoretical-practical balance of the educational process, which is developed by higher education institutions to generate knowledge and offer added value to the productive sector; precision that originated the idea of this article whose objective is to analyze the Factors that affect the productivity and competitiveness of the Faculty of Economic, Administrative and Accounting Sciences of the UDES Cúcuta within the framework of the Knowledge Economy; Its elaboration is based on a qualitative criterion methodology within a documentary investigation that analyzed the consultancies on the subjects of knowledge and interest for the present work, making possible the analysis of the conceptual foundations and the analysis of the results referring to the gaps between expectations of entrepreneurs and added value of the graduates of the Financial Administration, Public Accounting, Marketing and Advertising and Foreign Trade programs, based on the pertinent factors that affect the productivity and competitiveness of the programs, which led to the conclusion of that UDES, Cúcuta must restructure the curriculum and the institutional educational project according to areas of knowledge proposed through an action plan.

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Aibi, Revista de Investigacion Administracion e Ingenierias

Título del artículo:

Images in Clinical Tropical Medicine Dermatological Features as a Diagnostic Clue in Systemic Loxocelism Caused by Brown Recluse Spider Bite

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American Journal of Tropical Medicine and Hygiene

Título del artículo:

Analysis of the management of organic solid waste in Colombian companies based on the information from the industrial environmental survey EAI-2019

Introduction: This article reveals the problem of waste management by activities of companies and the destination given using the most recent information obtained from the industrial environmental survey EAI-2019 available through the National Administrative Department of Statistics (DANE). Materials and Methods: This study focuses on the amount of organic waste and its destination. For this, the variables are correlated: amount of organic waste and number of companies that take advantage of it for reuse according to the type of main activity of the companies. Results and Discussion: It was shown that only 65% of the companies measure the waste generated. The greater the amount of organic waste generated, the greater the amount that companies take advantage of for reuse, recycling or another modality. The predominant action is to deliver the waste to a third party that is in charge of the final destination with 56.9% of the companies, a figure that exceeds the 40.3% obtained from the sum of selling, donating or taking advantage of organic waste. Conclusions: There is evidence of a risk for measuring compliance with circular economy goals and for municipal development plans, taking into account that around 35% of companies do not measure waste. The commitment of companies to improve the volume of use of solid waste, even these can generate additional economic or energy resources according to the given destination. A good use of organic waste will contribute to the management of the circular economy to support the care of the environment.

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Innovaciencia

Título del artículo:

Parameters estimation in Rasch models for estimation of food insecurity in a population.

Introduction: The Food Insecurity Experience Scale is a methodological proposal of the Voices of the Hungry Project of the FAO Statistics Division; is a set of questions whose objective is the measurement of food insecurity as a latent trait. This question module can be included in a survey, then with the response matrix, is possible to calculate prevalences of food insecurity through a Rasch model using the sum of the affirmative answers obtained by a person to the questions of the FIES module as a sufficient statistic for the estimation of the latent trait: Food insecurity. Methodology: A response matrix to the FIES module was simulated in R. Then a Rasch model was applied to this response matrix in order to obtain the theta and beta parameters according to different inferential frameworks: maximum likelihood, Bayesian, marginal and conditional, different R packages were used according to each estimation. Results: The estimation of the parameters θ according to maximum likelihood and conditional estimation are not appropriate to estimate extreme scores. Conclusions: Bayesian and marginal estimation allow extreme scores for parameters θ, however, have high computational cost. The conditional estimate, which is the estimate currently used in the analytical protocol of the FIES scale at a global level, use pseudo scores to estimate the θ0 and θ8 and is the recommended estimation process if the severity of the latent trait in individuals/ households is the estimation required.

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Innovaciencia

Título del artículo:

Analysis of academic performance from a binary logistic regression model

Introduction: Comprehending the factors influencing students\' academic performance holds significant importance for the Universidad de Santander. This understanding enables the university to implement curricular adjustments and adaptations, which play a fundamental role in fostering the development of student competencies. Consequently, these adjustments contribute to enriching educational processes, thereby aiding in the successful fulfillment of the educational system\'s mission. Objective: To examine the factors influencing the academic performance of incoming students as opportunities for improvement that address the students\' needs. Materials and Methods: This study adopts an exploratory and cross-sectional design. Its comprised 1,161 new students. The response variable under consideration is the academic average attained by students at the conclusion of the academic semester. Data were sourced from national educational tests and institutional information systems. It was performed a statistical analysis using binary logistic regression, employing SPSS version 26 for the statistical software. Results and Discussion: An analysis of variance ANOVA F (2) = 24.94, p<.001 was performed, finding significant differences between the means of the average in the three campuses. The bivariate analysis using the Χ2(2) test = 26.72, p<.001, indicates that there is a statistically significant association between the academic average and the campus to which the students belong. Furthermore, the competencies assessed by the Saber 11 test, particularly the performance levels achieved in English and mathematics, were identified as crucial factors for the estimation of the academic performance model through binary logistic regression. Conclusions: Students who enter college with a stronger foundation in mathematics, critical reading, citizenship, and English proficiency experience enhanced consolidation within the college teaching and learning environment.

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Innovaciencia

Título del artículo:

Panorama of nursing research production in Colombia

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Revista Cuidarte

Título del artículo:

Validation of Nursing Outcome Indicators in Patients with Postsurgical Delirium

Objective. To validate the content of the indicators proposed from the Nursing Outcome Classification in a care plan for delirium management in older adults. Methods. Content validity study, conducted under the expert judgment technique. The procedure was developed in five moments: organization of indicators that respond to the nursing outcome classification for delirium management, support with literature of the indicators that responds to the result, selection of experts, establishment of agreements, and discussion. Quality criteria evaluated: pertinence and relevance, the Content Validity Coefficient and average scores assigned by the experts were calculated. Results. The study had the participation of 14 experts. The indicators, according to criteria of pertinence and relevance evaluated by experts showed a global average content index value of 0.93; 97.05% (66) of the indicators had Content Validity Coefficient?> 0.75. Conclusion. The quantitative findings of the indicator validation process showed high relevance and pertinence index, which favors their being applied to measure care changes in patients with delirium. Descriptors: validation study; delirium; adults; standardized nursing terminology; critical care units.

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Investigacion y Educacion en Enfermeria

Título del artículo:

Waist circumference cut-off points to identify major cardiovascular events and incident diabetes in Latin America: findings from the prospective Urban rural epidemiology study Colombia

Background: Abdominal obesity (AO) indirectly represents visceral adiposity and can be assessed by waist circumference (WC) measurement. In Latin America, cut-off points for the diagnosis of AO are based on Asian population data. We aim to establish the WC cut-off points to predict major cardiovascular events (MACE) and incident diabetes. Methods: We analyzed data from the cohort PURE study in Colombia. WC cut-off points were defined according to the maximum Youden index. Multivariate logistic regression was used to obtain associations between WC and MACE, diabetes, and cumulative incidence of outcomes visualized using Kaplan-Meier curves. Results: After a mean follow-up of 12 years, 6,580 individuals with a mean age of 50.7 ± 9.7 years were included; 64.2% were women, and 53.5% were from rural areas. The mean WC was 85.2 ± 11.6 cm and 88.3 ± 11.1 cm in women and men, respectively. There were 635 cases of the MACE composite plus incident diabetes (5.25 events per 1,000 person-years). Using a cut-off value of 88.85 cm in men (sensitivity = 0.565) and 85.65 cm in women (sensitivity = 0.558) resulted in the highest value for the prediction of the main outcome. These values were associated with a 1.76 and 1.41-fold increased risk of presenting the composite outcome in men and women, respectively. Conclusions: We defined WC cut-off points of 89 cm in men and 86 cm in women to identify the elevated risk of MACE and incident diabetes. Therefore, we suggest using these values in cardiovascular risk assessment in Latin America.

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Frontiers in Cardiovascular Medicine

Título del artículo:

Levy Rincón: the irascible opinion on YouTube

The article is based on the research \"Analysis of the content of the channels on YouTube, produced by Colombian independent video columnism\", whose general objective is to characterize the production of alternative opinion in Colombia, which is disseminated through the platform previously mentioned. The theoretical foundation that supports it is the academic literature related to the YouTube social media, where content different from that of the mainstream media circulates, and news values, a line of research in journalism studies. The methodology used was Content Analysis, with an Intercode Reliability and a Cohen\'s Kappa Coefficient of 20% of the sample. It concludes with the identification of 44 ways of expressing anger, mockery, criticism, and arguments, that the video columnist Levy Rincón uses in the production of his content, with a majority presence of two news values: prominence and negativity. In addition, with the construction of an opinion, whose content reuses the media production and uses different forms of argumentation.

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Observatorio

Título del artículo:

Higher education in Colombia: a reading of its educational policies aimed at teacher training and its didactic methods (1991 - 2016)

This paper aims to analyze didactic trends and university teacher training in Colombia, considering higher education policies from 1991 to 2016. Research, laws, and decrees focused on teacher training and its didactics methods are analyzed. It was evident that the different governments of the day have been implementing reforms in higher education, to improve the quality of teacher training. The analysis of the trends showed that Colombia in terms of education policies, the Constitution of 1991 and Law 30 of 1992, have not been sufficient to respond to the millennium change, in educational quality, research processes, and improvement of coverage education. Regarding didactic trends in teacher training, during the period 2001-2016, the law does not contemplate the issue of didactics.

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Estudios Pedagogicos

Título del artículo:

Structural analysis and cytotoxic evaluation of kisspeptin10 and analogs in types of cancer

The Kisspeptin system is a peptidergic system that plays a crucial role in regulating of reproduction and hormonal function. Kisspeptin is a peptide synthesized from the KiSS-1 gene and has been identified as the endogenous ligand of the kisspeptin receptor (KISS1R or GPR54 receptor). This system plays a key role in activating sex hormone secretion and puberty. In addition to its function in the regulation of reproduction, the Kisspeptin system has been found to play a role in other physiological processes, such as the regulation of appetite, energy metabolism, cardiovascular function, and cancer. In this study, several Kisspeptin analogs with structural modifications were designed and synthesized. The Kisspeptin analogs were evaluated by in vitro cytotoxicity tests on cancer cells of different cancer types. Cell viability assays were performed, and the concentrations that inhibited cell growth by a significant percentage were determined. The results showed that certain Kisspeptin analogs exhibited increased selective cytotoxicity in cancer cells compared to healthy cells. In conclusion, this study demonstrates that structurally modified Kisspeptin analogs have the potential to be therapeutic agents against some types of cancer. Understanding the structure-activity relationship of these analogs and their evaluation of their selective toxicity on cancer cells will be of great importance.

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Bionatura

Título del artículo:

Systematic review on the efficacy of behavioral activation therapy in the management of adult patients with depression

Introduction: This work aimed to assess the approach of behavioral activation for the treatment of adult patients diagnosed with depressive disorder; the importance of this study in the clinical setting is significant since it allowed us to know the viability and acceptability of the treatment. Behavioral activation is the basis of this study. Materials and method: Systematic review, under the PRISMA methodology, the PICO tool was implemented to formulate the research question. Results: 42 articles were located, of which, upon complete reading, 23 met the inclusion criteria established for the review. Analysis and discussion: The rationale of the studies found provided significant scientific evidence in favor of behavioral activation for adults diagnosed with depressive disorder. Conclusions: It was possible to deduce that behavioral activation is a key factor for the minimization of clinically significant symptoms in patients with depressive disorder.

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Gaceta Medica de Caracas

Título del artículo:

Meconium Peritonitis: Missed Opportunities and Diagnostic Challenges

Meconium peritonitis causes conditions such as adynamic ileus, intestinal obstruction by flanges, and short bowel in neonates. The clinical spectrum of this state can vary from a mild condition that does not require surgical management to a severe state that results in high mortality rate despite surgical correction. A male neonate was born at 37 weeks of gestation to a 25-year-old woman in Fundacion Cardiovascular de Colombia (Santander, Colombia). The neonate clinically deteriorated at birth, with abdominal distension and changes in the color of the abdominal wall. The condition was postnatally diagnosed as meconium peritonitis. The condition required surgical treatment in 2 stages—intestinal resection and double-mouth ileostomy with subsequent terminal anastomosis. The neonate was examined thoroughly to find the cause for the meconium peritonitis that is secondary to mechanical, physiological, or infectious obstruction.

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Perinatology

Título del artículo:

Recurrence of multisystem inflammatory syndrome associated with Covid-19 infection: case report

The COVID-19 pandemic has left millions of cases and deaths worldwide, in children the infection is less severe and has low mortality. A post-infectious entity called Systemic Multiinflammatory Syndrome (MIS-C) associated with COVID-19 infection is described, which has a mortality rate ten times higher than acute infection in children. MIS-C is characterized by sustained systemic inflammatory manifestations associated with fever and multiple system involvement. We present the case of a schoolgirl who presented a diagnosis of MIS-C with a good response to management and 11 months later, she presented a second episode that also responded to treatment. To date, we have not found in the literature the report of recurrence of MIS-C in children, such as the case presented by us, it marks an important precedent, inviting us to consider recurrence as a possibility in the case of a similar clinical presentation.

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Infectio

Título del artículo:

Measurement of Self-Concept: A Review

Self-concept is a psychological construct of great interest to psychology, demonstrated by the theoretical approach and the development of different forms for its measurement. In the present study, an initial conceptual path was made on the self-concept to show the agreement on its multidimensional character and the interaction spheres of the people in which it is evidenced. Similarly, a systematic review of psychometric studies that have reported the validity and reliability of different ways of measuring self-concept was made. A total of 44 investigations were found between 2010 and 2020 that met the defined inclusion criteria. The results of the analysis reveal the tendency to use internal consistency coefficients for reliability evidence, especially Cronbach\'s alpha; likewise, the frequent use of exploratory and confirmatory factor analysis for validity evidence. We highlight the demonstration of reliability and validity in different parts of the world and the languages of instruments, such as the Self-Concept Form 5 and the Self-Description Questionnaire. In the first, with few exceptions, the structure of five factors is corroborated in different contexts and languages; In the case of the second instrument, most studies vary in the number of factors extracted. Usually, the consistency values were greater than 0.7 in the different instruments; likewise, structure validity prevails. Again, attention is drawn to the little psychometric evidence in the measurement of self-concept in Colombia

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Psykhe

Título del artículo:

Malignant Gliomas: Anaplastic Astrocytoma, Glioblastoma, Gliosarcoma, and Anaplastic Oligodendroglioma

This chapter compiles a detailed description of the epidemiology, histopathology, imaging, treatment and new advances in malignant gliomas. This includes the most common malignancies of the primary CNS in adults: glioblastoma, anaplastic astrocytoma, gliosarcoma, anaplastic oligodendroglioma (AO), midline glioma and gliomatosis cerebri. We present the recent clinical trials and therapeutic advances that have slowly but steadily lengthened the survival of patients with these tumors, including tumor treatment field technology. A noticeable change in this edition is the adoption of the latest 2016 World Health Organization (WHO) classification. The 2016 WHO classification restructured the malignant glioma family by using molecular parameters in addition to histology to define several brain tumor entities. New entities such as glioblastoma, IDH wild-type; glioblastoma, IDH mutant; and diffuse midline gliomas (H3K27M mutated) are presented in this chapter. At the end of the text, the reader can find a special section for AOs and midline gliomas. Adding this information was deemed important due to the prognostic implications and management of these specific lesions.

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Youmans and Winn Neurological Surgery: Volumes 1-4, 8th Edition

Título del artículo:

Business productivity and union ethics: a look at Colombia

This text is born from the research project in business management that is being carried out in the business administration program where the authors are linked. The pursuit of business success and union ethics are presented as the purpose of consolidating Latin American sustainable development. In this sense, the new labor realities have recently been focusing on productivity, on the elimination of static work giving rise to remote work and the formation of synergistic work teams, which respond to the inclinations of this new offspring of subordinates, thus affecting to the trade union organizations that depend on the labor cloister.

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Human Review. International Humanities Review / Revista Internacional de Humanidades

Título del artículo:

Letter to the editor: tool for the scientific initiation of medical students

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Acta Neurologica Colombiana

Título del artículo:

Bullerengue: Approach to this Afro-Colombian manifestation from performance studies

This article is an approximation to bullerengue from the performance studies as a lens for the analysis which tries to transcend the panoramic-descriptive or specific disciplinary views which this cultural manifestation has been approached with and presents an integrative theoretical perspective. It means a comprehensive and integral effort of what has commonly been separated as song, dance or party in most of the existing studies in the field, taking as an axis its interconnections, dialogues and its meanings as well as the connotations for the actors involved specifically in the context of Urabá (region located in the north-west of Colombia). This process is framed on a recent research experience, a project called Bullerengue in Urabá, an approach to a complex socio-cultural manifestation (2018-2019), whose focus procures the integration of ethnomusicology, dance studies and ethnography.

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Memorias

Título del artículo:

Comment on: UK pediatric surgical academic output (2005–2020): A cause for concern?

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Journal of Pediatric Surgery

Título del artículo:

Comparison of the social profile of individuals accused of crime of \"infidencia\" in the Independence Wars of Mexico and Venezuela, 1809-1820

The article compares the social profile of individuals accused of \"infidencia\" in the context of the Independence Wars of the current countries of Mexico and Venezuela from 1809 to 1820. The sources known as \"las causas de infidencia\" were consulted and selected from a sample of 534 individuals accused of \"infidencia\" in Mexico and 534 in Venezuela. The variables used in the analysis were age, occupation, ethnic group, crime committed, and sentence received. The study yielded some elements that contribute to the comparative studies in understanding the subjects who participated in the Spanish-American independence movements.

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Trashumante

Título del artículo:

RECONSTRUCTION OF THE SOCIAL FABRIC IN HUMANITARIAN EMERGENCIES: THE CONTEMPORARY ROLE OF THE FAMILY

The main objective of this paper is to analyze the current political institutional crises in some Latin American countries, which are accelerating changes and rebuilding the social fabric towards a new institutional order, seeking to influence collective consciences. The paper examines the reconstruction of the national body as a precondition for the democratic transitions taking shape in these countries. The article concludes the need for such a transition with processes of amnesty, national reconciliation, reconstruction of the social fabric, and reparation for the victims of human rights violations, with a great deal of coordination among all actors and civil society, especially families.

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Novum Jus